While the opiate receptor relies on G protein coupling for signal transduction, this receptor was located to benefit from arrestin activation for internalization of the receptor. Normally, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable enhancement in binding efficacy. This binding ultima… Read More


While it is actually mysterious no matter whether other not known interactions are transpiring within the receptor that add to its results, the receptor plays a task as being a damaging down regulator of endogenous opiate levels by way of scavenging exercise. This drug-receptor conversation features an alternative choice to manipulation with the cl… Read More